What Changed

When the label changed, and what it said before

Read this first. An FDA label is revised for many reasons, and most of them are not safety findings — a manufacturer changes, a section is reformatted, a typographic correction is filed. A revision appearing here means the label document changed on the date shown. It does not by itself mean the drug became more dangerous, and this page never says that it did.

Where we can see which section changed, we say so. Where we cannot, we say that too rather than guessing. Nothing here is medical advice, and no entry is a reason to start or stop a medication on your own.

Every medication in our library is checked against the FDA’s own Structured Product Labels. We follow each drug by its label’s permanent document ID, so a revision recorded here is a change to that document, not a different company publishing its own copy of the same text. This record began on September 6, 2026, and was last checked on October 24, 2026.

  1. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 24, 2026. FDA Structured Product Label via openFDA and DailyMed

  2. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 24, 2026. FDA Structured Product Label via openFDA and DailyMed

  3. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 23, 2026. FDA Structured Product Label via openFDA and DailyMed

  4. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 23, 2026. FDA Structured Product Label via openFDA and DailyMed

  5. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 22, 2026. FDA Structured Product Label via openFDA and DailyMed

  6. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 22, 2026. FDA Structured Product Label via openFDA and DailyMed

  7. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 21, 2026. FDA Structured Product Label via openFDA and DailyMed

  8. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 21, 2026. FDA Structured Product Label via openFDA and DailyMed

  9. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 20, 2026. FDA Structured Product Label via openFDA and DailyMed

  10. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 20, 2026. FDA Structured Product Label via openFDA and DailyMed

  11. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 19, 2026. FDA Structured Product Label via openFDA and DailyMed

  12. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 19, 2026. FDA Structured Product Label via openFDA and DailyMed

  13. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 18, 2026. FDA Structured Product Label via openFDA and DailyMed

  14. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 18, 2026. FDA Structured Product Label via openFDA and DailyMed

  15. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 16, 2026. FDA Structured Product Label via openFDA and DailyMed

  16. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 16, 2026. FDA Structured Product Label via openFDA and DailyMed

  17. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 15, 2026. FDA Structured Product Label via openFDA and DailyMed

  18. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 15, 2026. FDA Structured Product Label via openFDA and DailyMed

  19. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 14, 2026. FDA Structured Product Label via openFDA and DailyMed

  20. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 14, 2026. FDA Structured Product Label via openFDA and DailyMed

  21. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 13, 2026. FDA Structured Product Label via openFDA and DailyMed

  22. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 13, 2026. FDA Structured Product Label via openFDA and DailyMed

  23. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 12, 2026. FDA Structured Product Label via openFDA and DailyMed

  24. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 12, 2026. FDA Structured Product Label via openFDA and DailyMed

  25. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 11, 2026. FDA Structured Product Label via openFDA and DailyMed

  26. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 11, 2026. FDA Structured Product Label via openFDA and DailyMed

  27. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 10, 2026. FDA Structured Product Label via openFDA and DailyMed

  28. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 10, 2026. FDA Structured Product Label via openFDA and DailyMed

  29. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 9, 2026. FDA Structured Product Label via openFDA and DailyMed

  30. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 9, 2026. FDA Structured Product Label via openFDA and DailyMed

  31. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 8, 2026. FDA Structured Product Label via openFDA and DailyMed

  32. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 8, 2026. FDA Structured Product Label via openFDA and DailyMed

  33. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 7, 2026. FDA Structured Product Label via openFDA and DailyMed

  34. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 7, 2026. FDA Structured Product Label via openFDA and DailyMed

  35. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 6, 2026. FDA Structured Product Label via openFDA and DailyMed

  36. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 6, 2026. FDA Structured Product Label via openFDA and DailyMed

  37. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 5, 2026. FDA Structured Product Label via openFDA and DailyMed

  38. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 5, 2026. FDA Structured Product Label via openFDA and DailyMed

  39. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 4, 2026. FDA Structured Product Label via openFDA and DailyMed

  40. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 4, 2026. FDA Structured Product Label via openFDA and DailyMed

  41. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 3, 2026. FDA Structured Product Label via openFDA and DailyMed

  42. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 3, 2026. FDA Structured Product Label via openFDA and DailyMed

  43. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 2, 2026. FDA Structured Product Label via openFDA and DailyMed

  44. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 2, 2026. FDA Structured Product Label via openFDA and DailyMed

  45. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected October 1, 2026. FDA Structured Product Label via openFDA and DailyMed

  46. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected October 1, 2026. FDA Structured Product Label via openFDA and DailyMed

  47. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 30, 2026. FDA Structured Product Label via openFDA and DailyMed

  48. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 30, 2026. FDA Structured Product Label via openFDA and DailyMed

  49. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 28, 2026. FDA Structured Product Label via openFDA and DailyMed

  50. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 28, 2026. FDA Structured Product Label via openFDA and DailyMed

  51. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 27, 2026. FDA Structured Product Label via openFDA and DailyMed

  52. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 27, 2026. FDA Structured Product Label via openFDA and DailyMed

  53. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 26, 2026. FDA Structured Product Label via openFDA and DailyMed

  54. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 26, 2026. FDA Structured Product Label via openFDA and DailyMed

  55. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 25, 2026. FDA Structured Product Label via openFDA and DailyMed

  56. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 25, 2026. FDA Structured Product Label via openFDA and DailyMed

  57. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 24, 2026. FDA Structured Product Label via openFDA and DailyMed

  58. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 24, 2026. FDA Structured Product Label via openFDA and DailyMed

  59. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 23, 2026. FDA Structured Product Label via openFDA and DailyMed

  60. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 23, 2026. FDA Structured Product Label via openFDA and DailyMed

  61. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 22, 2026. FDA Structured Product Label via openFDA and DailyMed

  62. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 22, 2026. FDA Structured Product Label via openFDA and DailyMed

  63. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 21, 2026. FDA Structured Product Label via openFDA and DailyMed

  64. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 21, 2026. FDA Structured Product Label via openFDA and DailyMed

  65. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 20, 2026. FDA Structured Product Label via openFDA and DailyMed

  66. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 20, 2026. FDA Structured Product Label via openFDA and DailyMed

  67. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 19, 2026. FDA Structured Product Label via openFDA and DailyMed

  68. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 19, 2026. FDA Structured Product Label via openFDA and DailyMed

  69. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 18, 2026. FDA Structured Product Label via openFDA and DailyMed

  70. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 18, 2026. FDA Structured Product Label via openFDA and DailyMed

  71. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 17, 2026. FDA Structured Product Label via openFDA and DailyMed

  72. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 17, 2026. FDA Structured Product Label via openFDA and DailyMed

  73. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 16, 2026. FDA Structured Product Label via openFDA and DailyMed

  74. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 16, 2026. FDA Structured Product Label via openFDA and DailyMed

  75. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 15, 2026. FDA Structured Product Label via openFDA and DailyMed

  76. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 15, 2026. FDA Structured Product Label via openFDA and DailyMed

  77. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 14, 2026. FDA Structured Product Label via openFDA and DailyMed

  78. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 14, 2026. FDA Structured Product Label via openFDA and DailyMed

  79. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 13, 2026. FDA Structured Product Label via openFDA and DailyMed

  80. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 13, 2026. FDA Structured Product Label via openFDA and DailyMed

  81. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 12, 2026. FDA Structured Product Label via openFDA and DailyMed

  82. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 12, 2026. FDA Structured Product Label via openFDA and DailyMed

  83. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 11, 2026. FDA Structured Product Label via openFDA and DailyMed

  84. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 11, 2026. FDA Structured Product Label via openFDA and DailyMed

  85. lisdexamfetamine

    Effective August 11, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 24 → 25, previously effective August 28, 2026. Detected September 10, 2026. FDA Structured Product Label via openFDA and DailyMed

  86. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 10, 2026. FDA Structured Product Label via openFDA and DailyMed

  87. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 9, 2026. FDA Structured Product Label via openFDA and DailyMed

  88. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 8, 2026. FDA Structured Product Label via openFDA and DailyMed

  89. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 7, 2026. FDA Structured Product Label via openFDA and DailyMed

  90. trazodone

    Effective September 1, 2026

    • The boxed warning text changed.
    • The drug interactions section changed.

    Label document version 5 → 6, previously effective August 27, 2026. Detected September 6, 2026. FDA Structured Product Label via openFDA and DailyMed

How this is built

Drug labels in the United States are filed as Structured Product Labels, and each one carries a permanent document ID and a version number that increments when the labeler files a revision. We store the version we last saw for every medication in our library and compare it against the FDA’s current one. When it moves, the change is recorded here with the date the new label took effect and a link to the document itself, so you can read it rather than take our word for it.

One honest limit: the FDA publishes the current label, not a diff. We can tell you a section changed and when, and we can link you to what it says now. We cannot show you the removed wording unless we happened to be watching before it went.

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