Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode…
Given quetiapine's middle-of-the-pack efficacy ranking, what made it the right antipsychotic for my situation compared with the alternatives?
Top of the evidence hierarchy, independently funded. how we score evidence
Across 402 randomized trials covering 53,463 adults with schizophrenia, quetiapine ranked mid-field of 32 antipsychotics for symptom reduction, with low rates of movement side effects but more sedation and a small QTc prolongation (about 3 ms) versus placebo.
Worth asking
Given quetiapine's middle-of-the-pack efficacy ranking, what made it the right antipsychotic for my situation compared with the alternatives?
What it is FDA approved for
Read off the label. Trial duration and approval year are shown only where they were recorded — never inferred.
- Schizophrenia (adults; adolescents 13-17)
- Bipolar I disorder, acute manic episodes (monotherapy or adjunct to lithium/divalproex; ages 10-17 monotherapy)
- Bipolar disorder, acute depressive episodes (monotherapy) · trials ran 8-week randomized trials
- Bipolar I disorder, maintenance treatment (adjunct to lithium or divalproex)
- Major depressive disorder, adjunctive treatment with antidepressants (Seroquel XR only)
Source
Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis — Huhn M, et al. (2019)
Top-tier peer-reviewed journal
Read the source: https://doi.org/10.1016/S0140-6736(19)31135-3
DOI: 10.1016/S0140-6736(19)31135-3
How this was scored
- Study design
- Meta-analysis of randomised trials
- Funding
- Independently funded
- Published in
- Top-tier peer-reviewed journal
- Sample size
- 53,463
- Preregistered
- Yes
- Conflicts disclosed
- Yes
- Independent of proponent
- Yes
- Retracted
- No
Read the full scoring rubric, including what it can't tell you.
Published August 19, 2026.
Questions
How strong is the evidence behind this?
Resolv rates this source "gold standard". Top of the evidence hierarchy, independently funded. It scores 100 out of 100 on our published rubric. The score is calculated from recorded facts about the source — study design, funding, publication venue, sample size, preregistration — not typed in by an editor.
What is the source for this?
Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis — Huhn M, et al. (2019). Published in: Top-tier peer-reviewed journal. DOI: 10.1016/S0140-6736(19)31135-3. The full source is linked on this page so you can read it yourself.
Who paid for this research, and does that matter?
Study design: Meta-analysis of randomised trials. Funding: Independently funded. The researchers were independent of whoever benefits from the result. Industry sponsorship is one of the most reliably measured biases in medicine, which is why funding carries real weight in the score rather than sitting in a footnote.
Is quetiapine (Seroquel), seroquel FDA approved?
Yes — FDA approved for Schizophrenia (adults; adolescents 13-17), Bipolar I disorder, acute manic episodes (monotherapy or adjunct to lithium/divalproex; ages 10-17 monotherapy), Bipolar disorder, acute depressive episodes (monotherapy), Bipolar I disorder, maintenance treatment (adjunct to lithium or divalproex), Major depressive disorder, adjunctive treatment with antidepressants (Seroquel XR only). Approval is for a specific indication, not for everything the drug is prescribed for.
Is this medical advice?
This is information to bring to your prescriber, not medical advice and not a reason to change anything on your own. Nothing here is an instruction to stop or reduce a medication. If you are in crisis, call or text 988.
This is information to bring to your prescriber, not medical advice and not a reason to change anything on your own. Nothing here is an instruction to stop or reduce a medication. If you are in crisis, call or text 988.